Microbiome & Chronic Diseases

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Branched-chain amino acids {90000344}

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Branched-chain amino acids
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Shared Reference Notes

  • [1.1
    - BCAAs valine, leucine, and isoleucine are possible biomarkers in human carcinogens owing to their requirement in cancer cell growth and tumor progression. - BCAAs are involved in carcinogenesis and metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes (T2D), sports supplements with these amino acids might improve strenuous training.
  • [1.2] [#Branched short-chain fatty acids, #Isobutyric acid, #Isovaleric acid] [#High-protein diet
    - Both isobutyric and isovaleric acids are BSCFAs, which are produced by fermentation of branched-chain amino acids by intestinal flora. Milk and dairy products are unique dietary sources of BCFAs. - Higher levels of BCFAs are produced when eating a high-protein/low-carbohydrate diet
  • [#Gestational diabetes mellitus (GDM), #Pregnancy] [#Short Chain Fatty Acid] In GDM: - Isobutyric, isovaleric, valeric, and hexanoic acids were significantly higher in the GDM. - #Isobutyric acid significantly correlated with urea and blood glucose at 1 and 2 hours after OGTT; fasting blood glucose, blood glucose at 2 hours after OGTT. - urea/creatinine ratio positively correlated with #Valeric acid. - blood glucose at 2 hours after OGTT positively correlated with #Caproic acid. - white blood cell count positively correlated with #Propionic acid. - Significantly elevated #Isobutyric acid and isovaleric acid in pregnant women with GDM may be associated with insulin resistance caused by BCFAs.

References Notes

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