Short Chain Fatty Acid ⇒ Propanoic acid {90000664} Record Keys Parent:Short Chain Fatty Acid Definition:Propanoic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Autism] [#Butanoic acid] - GM core volatilome for all ASD patients was characterized by over-production of 1-pentanol, 1-butanol, phenyl ethyl alcohol; benzeneacetaldehyde, octadecanal, tetradecanal; #Methyl isobutyl ketone, 2-hexanone, acetone; acetic, propanoic, 3-methyl-butanoic and 2-methyl-propanoic acids; #Indole and #Skatole; and o-cymene. [#Autism] [#Butanoic acid, #Short Chain Fatty Acid] - a bi-directional perturbation of the dopaminergic pathways by both propanoic and butanoic acids has been described, suggesting that a similar dysregulation of brain catecholaminergic system occurs, as a response, in the presence of excessive concentrations of SCFA [#Autism] - propanoic acid has been shown to induce hyperactivity, monotonous behaviors, impaired social behavior, increased repetitive locomotor activity, caudate spiking, and an innate neuroinflammatory response in ASD patients [#Autism] [#Short Chain Fatty Acid] - propanoic acid was associated with the CBCL_EXT scale for ASDs with risk of symptoms, compared to ASDs without clinical symptoms, hence suggesting a role for SCFAs in the manifestation of behavioral problems. [#Blood Brain Barrier Integrity] - propanoic acid passes the gut-blood and blood–brain barriers, it could travel from the intestine to the CNSReferences Notes[ ]
