Disease ⇒ Rheumatic Hearth Disease {40000131} Record Keys Type:Disease Parent:[ ] Definition:Rheumatic Hearth Disease Details Initialisation date:2021-03-10 Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:Cardiovascular, Immunology Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - The patients possessed higher levels of genera including Bifidobacterium and Eubacterium, and lower levels of genera including Lachnospira, Bacteroides, and Faecalibacterium. Coprococcus was identified as a super-generalist in fecal samples of the patients. Significant alterations were also observed in microbiota of subgingival plaques and saliva of the patients compared to control subjects. [1.2] [#Atherosclerosis] [#Porphyromonas gingivalis] - Oral microbes, including P. gingivalis, #Actinomyces, #Streptococcus, and #Treponema denticola, have been confirmed as sources of infected heart valves, atherosclerotic plaques, and rheumatic heart valves [1.3] [#Hearth attack] - Sodium #Butyrate, a metabolite of the gut microbiota, inhibited the activation of the NLRP3/Caspase-1 pyroptosis pathway in TGFβ1-induced Cardiac fibroblasts, repressed the transdifferentiation of Cardiac fibroblasts into myofibroblasts.References Notes[ ]
