Collagen {90000624} Record Keys Parent:[ ] Definition:Collagen Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Skin aging] [#Streptococcus infantis, #Streptococcus pneumoniae] [#Aging] - younger Korean women carried a higher amount of skin #Streptococcus compared to older Korean women. - These #Streptococcus species, specifically #Streptococcus (St.) pneumoniae and St. infantis, can secrete substances that up-regulate collagen synthesis. [1.2] [#Streptococcus mutans] - about 20% clinical isolates of S. mutans have the cnm gene, which codes for a glycosylated collagen- and laminin-binding surface adhesion > infection and an elevated risk of caries development > cnm may play a role in #Amyloid aggregation through the collagen-binding domain (CBD) of cnm > cnm is a major amyloidogenic protein in S. mutans biofilms. [1.3] - #GABA plays multiple roles in maintaining skin health, including the inhibition of itching by acting as a neurotransmitter, attenuating skin lesions by balancing Th1 and Th2 levels, and maintaining skin elasticity by increasing the expression of type I collagen. [1.4] [#Multiple Sclerosis] - the abundance of #Actinomyces genus, along with several #Actinomycetales compounds increased in the gut of MS patients. - there is a peptide from #Actinomyces can mimic collagen type IV α3127–148 and become a source of autoimmunity, thus leading to anti-glomerular basement membrane disease in HLA DRB1*15:01 humanized mice [1.5] [#Butyrate] - In mice with collagen-antibody-induced arthritis (a model of #Rheumatoid Arthritis) and with experimental autoimmune encephalomyelitis (a model of #Multiple Sclerosis) > SerBut substantially ameliorated disease severity, modulated key immune cell populations systemically and in disease-associated tissues, and reduced inflammatory responses without compromising the global immune response to vaccination. [1.6] - #TMAO induced increased renal fibroblast proliferation and collagen production via Akt and mTOR, but not via PI3KReferences Notes[ ]
