Linoleic acid {90000294} Record Keys Parent:[ ] Definition:Linoleic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-cancer Notes: [ ]Shared Reference Notes [1.1] [#Hepatocellular cancer] - hepatocellular carcinoma patients had significantly decreased linoleic acid and #Phenol levels in serum and feces, two metabolites that significantly inhibit the growth of hepatocellular carcinoma cells. [1.2] [#Omega 3] - After 10 weeks of omega-3 fatty acid or γ-linoleic acid supplementation, inflammatory and non-inflammatory #Acne lesions decreased significantly. [1.3] [#Cancer] - Linoleic acid (LA) is a major positive regulator of CTL ( Cytotoxic T Cell Lymphocytes ) activity by improving metabolic fitness, preventing exhaustion, and stimulating a memory-like phenotype with superior effector functions. - LA potentiates antitumor CTL response. [1.4] [#Soybean] - Soybeans also contain higher amounts of polyunsaturated fatty acids, including both omega-6 and omega-6 essential fatty acids, linoleic acid and alpha-linolenic acid, than other common legumes [1.5] [1.6] [#Creutzfeldt–Jakob disease] - metabolites in sCJD, related to linoleic acid metabolism and steroid hormone biosynthesis might be biomarkers of evaluating disease severity. [1.7] - linoleic acid, a fatty acid required for acylceramide synthesis and essential for corneocyte lipid envelope formation. - This fatty acid is decreased in the epidermis in patients with ichthyosis, and #Acne-prone patients have low concentrations of linoleic acid and a relative lack of ceramide. [#Cutibacterium acnes] - lipidomic analyses showed an increase of triglycerides containing linolenic acid (TAG18:2) and an increase of total ceramide in NHEKs after C. acnes exposure. - linoleic acid may be hydrolyzed from TAG and then contribute to acylceramide synthesis to maintain skin barrier function. [#Cutibacterium acnes] - Linoleic acid in NHEK lipid extract could partially explain the increased potency for C. acnes inhibition and has previously been shown to directly inhibit the growth of C. acnesReferences Notes[ ]
