Ellagic acid {90000309} Record Keys Parent:[ ] Definition:Ellagic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory Notes: [ ]Shared Reference Notes [1.1] - #Gordonibacter genus and #Clostridium coccoides group are responsible for the generation of #Urolithins by the metabolism of Ellagic acid [1.2] - 3,8-Dihydroxy-urolithin (#Urolithin A), a metabolite of ellagic acid which is found in high levels in pomegranate, acts on the #AHR and nuclear factor erythroid 2–related factor 2 (NRF2) signalling pathways to upregulate the expression of TJs proteins and ameliorate #Colitis - #Urolithin A is an agonist of #AHR able to reduce the expression of inflammatory genes. [1.3] [#Epigallocatechin gallate] - a #Pomegranate extract was shown to reduce microgliosis and #Amyloid-beta plaque deposition in association with reduced #Anxiety-like behavior and increased memory performance. - This effect was attributed to two polyphenolic compounds, #Punicalagin and ellagic acid, and likely its bioactive microbial-derived metabolite EGCG [#Gordonibacter pamelaeae] [#Ellagitannins] - The #Urolithins are an important class of bioactive microbial metabolites derived from ellagitannin and ellagic acid precursors. - Several bacterial species have been identified that produce their intermediate metabolites including #Gordonibacter urolithinfaciens and G. pamelaeae. [1.4] - #Urolithin A (UA), a microbial metabolite generated from plant-based ellagic acid, could regulate the neutrophil myeloperoxidase defence mechanism [1.5] [#Cognitive impairment] [#Polyphenols, #Urolithins] - #Gordonibacter pamelaeae, also has a unique metabolism that may affect the brain, as it can metabolize the polyphenol ellagic acid (found in pomegranates and some berries) into urolithin, which has been shown in some studies to have a neuroprotective effectReferences Notes[ ]
