Trigonelline {90000630} Record Keys Parent:[ ] Definition:Trigonelline Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - TG promotes the regeneration of dendrites and axons in cortical neurons and inhibits the formation of advanced glycation end products in vitro, and improves learning and memory impairment in the in vivo models of #Alzheimer’s disease and neuroinflammation [#Cognitive impairment] [#Lipopolysaccharide] - TG-treated SAMP8 mice exhibited significant improvement in the parameters of escape latency, distance moved, and annulus crossing index. - Trigonelline treatment significantly reduces TNFα and IL6 protein levels in SAMP8 mice hippocampus. - it also suppressed LPS-induced TNFα mRNA expression in SH-SY5Y cells. - TG may exert its biological effects through negatively modulating Traf6-mediated NF-κB activation. [#Niacin] - trigonelline (TG), a naturally occurring alkaloid compound (N-methyl nicotinic acid) found in various plants, including #Coffee beans, fenugreek, and Japanese radish [1.2] - Dietary trigonelline supplementation in male mice enhances #Muscle strength and prevents #Fatigue during ageing. [#Sarcopenia] - trigonelline improved grip strength and #Fatigue independently of changes in muscle mass and maximal tetanic strength. - benefits of trigonelline on muscle performance did not arise from structural adaptations in the skeletal muscle architecture, such as myofibre cross-sectional area, vascularization and fibrosis, but were linked to functional improvements of the mitochondrial respiratory activity of complexes I and II. [#High fibre diet] - dietary intake of #Folate and fibre was linked to circulating trigonelline levels. - In humans, serum trigonelline levels are reduced with #Sarcopenia and correlate positively with #Muscle strength and mitochondrial oxidative phosphorylation in skeletal muscle. - urinary trigonelline levels decrease during #Obesity and increase in professional #Athletes - trigonelline incorporates into the NAD+ pool and increases NAD+ levels in #Caenorhabditis elegans, mice and primary myotubes from healthy individuals and individuals with #Sarcopenia. - trigonelline is particularly abundant in plant-derived food products, such as #Coffee beans and fenugreek seeds, which have been reported to modulate endogenous trigonelline levels in humans. - high #Coffee consumption has been associated with a lower prevalence of #Sarcopenia in some populations - trigonelline can be produced by the microbiome.References Notes[ ]
