Natural Med. Cond. ⇒ Skin aging {40000638} Record Keys Type:Natural Med. Cond. Parent:[ ] Definition:Skin aging Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#UV radiation] - Chronic UV exposure induces #Reactive Oxygen Species (ROS) production, activating three major skin #Aging cascades. - Resveratrol > prevent photo-#Aging through anti-inflammatory, antioxidant, and antitumour pathways. - The viability of cultured human keratinocytes (HaCaT cell line) pretreated with different doses of resveratrol significantly increased up to 94%. - night-time topical antioxidant containing #Resveratrol, baicalin, and #Vitamin E for 12 weeks. - significant increase in collagen type II alpha 1 gene expression. - Supported with a clinical improvement in elasticity and skin thickness as measured by ultrasound. [#UV radiation] - In mice > oral or topical administration of #Resveratrol resulted in a suppression of UVB-induced epidermal thickening. [1.2] [#Corynebacterium kroppenstedtii] - Cor. kroppenstedtii was likely responsible for the observed #Aging-related increase in #Corynebacterium. [#Cutibacterium acnes] - C. acnes clade C is functionally related to skin aging. [#Cutibacterium acnes] - C. acnes was likely responsible for the #Aging-related depletion of #Cutibacterium - #Glyoxylate bypass pathwayup-regulation is observed during #Oxidative stress – a characteristic of skin aging. [#Streptococcus infantis, #Streptococcus pneumoniae] [#Aging] - younger Korean women carried a higher amount of skin #Streptococcus compared to older Korean women. - These #Streptococcus species, specifically #Streptococcus (St.) pneumoniae and St. infantis, can secrete substances that up-regulate #Collagen synthesis.References Notes[ ]
