Neurotransmitters ⇒ Dopamine {60000054}
| Parent: | |
|---|---|
| Definition: | Dopamine |
| Queue: | [ ] |
| Initialisation date: | 2020-09-16 |
|---|---|
| Specification: | |
DA, a contraction of 3,4-dihydroxyphenethylamine | |
| Source: | |
| [ ] | |
| Structural Type: | Catecholamine |
|---|---|
| Functional Type: | Hormon |
| Function: | [ ] |
Notes:
[ ]
Shared Reference Notes
- [1.1]
- #Bacillus can produce dopamine. - [1.2]
- #Bacillus spp. produces Dopamin - [1.3] [#Parkinson’s Disease]
- Tyrosine decarboxylase (TyrDC), present in gut microbes, converts #L-Dopa into dopamine, which does not cross the blood-brain barrier and accumulates in the gut, causing many side effects such as cardiac arrhythmias and nausea. - levodopa can be metabolized by Clostridium sporogenes to 3-(3,4-dihydroxyphenyl) propionic acid (#DHPPA), a metabolite that inhibits muscle contraction in the ileum, reduces intestinal movement, and impairs absorption in the small intestine. - [1.4] [#Parkinson’s Disease]
- #Vitamin B6 is a critical cofactor for a wide range of biochemical reactions, including the synthesis of dopamine. - #Vitamin B6 intake was associated with a reduced risk of developing PD. - [1.5] [#Parkinson’s Disease]
- elevated levels of #Tyrosine decarboxylase/aspartate 1-decarboxylase gene-family, which removes #Tyrosine, a required precursor of dopamine.
References Notes
[ ]