Docosahexaenoic acid {90000627} Record Keys Parent:[ ] Definition:Docosahexaenoic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Juvenile idiopathic arthritis] - Low levels of #Arachidonic acid (AA) and docosahexaenoic acid (DHA) have been described in the active phase of JIA, with total n-3 polyunsaturated fatty acids (PUFAs) lower in JIA and negatively correlated with inflammation. [1.2] [#Autism] - decrease in crucial lipids, like LA and α-#Linolenic acid (ALA), bile acids, and TGs in neonates with future ASD, together suggests pro-inflammatory events present at birth. - LA and ALA are precursors to long-chain polyunsaturated fatty acids (PUFAs) like docosahexaenoic acid (DHA, 22:6n-3), which have anti-inflammatory effects on the brain and regulate autophagy, neurotransmission, and neurogenesis > through inhibition of neurotransmitter release, e.g., γ-aminobutyric acid (#GABA), influences synaptic function and plasticity.References Notes[ ]
