Disease ⇒ Familial adenomatous polyposis {40000208} Record Keys Type:Disease Parent:[ ] Definition:Familial adenomatous polyposis Details Initialisation date:[ ] Other Terms:FAP Meta Information MedDra ID:10056981 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Enterotoxigenic #Bacteroides fragilis (ETBF) is present in colonic mucosa of people with familial adenomatous polyposis and promotes oncogenic processes in a tumour-prone mice model. - ETBF does not cause a unique mutational signature unlike the SBS88 and ID18 signatures associated with pks+ E. coli. - epithelium exposed to ETBF undergoes inflammation-driven tumorigenesis and caused a unique DNA methylation signature References Notes[ ]
