Phenethylamine {90000547}

Shared Reference Notes

• [1.1] [#Clostridium boltae] 
  - #Blautia hansenii, Enterocloster (Clostridium) boltae and #Enterococcus faecalis and have also been shown to produce #Tryptamine and phenethylamine by recent studies
• [#Diabetes Type 2, #Irritable bowel syndrome] [#Ruminococcus gnavus] [#High fibre diet] - fiber intervention significantly suppressed #Tryptamine and phenethylamine levels and abundances of R. gnavus in T2D subjects, revealing manipulation of gut microbiota-derived #Tryptamine and phenethylamine by dietary changes or prebiotics is a potential direction for managing #Metabolic syndrome and IBS.
• [#Diabetes Type 2] [#Blautia hansenii] - increased abundances of other #Tryptamine and phenethylamine producer B. hansenii in #Metabolic syndrome
• [#Diabetes Type 2] - #Tryptamine and phenethylamine can stimulate insulin secretion but both acute and long-term exposure to TAAR1 activators #Tryptamine and phenethylamine impair insulin sensitivity
• [#Diabetes Type 2] [#Ruminococcus gnavus] - #Tryptamine/phenethylamine-mediated TAAR1 signaling pathway as the key molecular axis underlying R. gnavus-induced insulin resistance
• - TAAR1 is an amine-activated G protein-coupled receptor that is activated by gut microbes-derived aromatic trace amines including #Tryptamine, phenethylamine, and #Tyramine in gut
• [#Ruminococcus gnavus] - #Tryptamine and phenethylamine as TAAR1 ligands are the culprits and one possible way to design a therapeutic approach is to facilitate the reduction of R. gnavus or on top of blocking the #Tryptamine and phenethylamine production by inhibiting the bacterial TDC
• [#Ruminococcus gnavus] - R. gnavus reduction accompanied by downregulation of #Tryptamine and phenethylamine are positively correlated with the improvement of insulin resistance.
• [#Ruminococcus gnavus] - Among these #Tryptamine and phenethylamine-producing bacteria species, R. gnavus has the highest catalytic ability to transform aromatic amino acids into aromatic trace amines (#Tryptamine, #Tyramine, and phenethylamine) compared with other bacteria specie
• [1.2] [#Alzheimer’s disease] 
  - phenethylamine reduced the p-#Tau levels in AD patient iPSC-derived neurons. Phenethylamine, a trace amine, has been associated with reduced risk of AD.

References Notes