Sirtuin {90000406} Record Keys Parent:[ ] Definition:Sirtuin Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Olive oil > #Oleic acid (OA) content (70–80%) is responsible for its many health properties. - The best-characterized mechanism highlights OA as a natural activator of sirtuin 1 (SIRT1). - #Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. [1.2] [#Diabetes Type 2, #Obesity] - #Resveratrol mimics #Caloric restriction via the activation of sirtuin 1 (SIRT 1) resulting in improved exercise performance and insulin sensitivity, as well as showing body fat-lowering effects by inhibiting adipogenesis, and increasing lipid mobilisation in adipose tissue. [#Skin wound] - proangiogenic properties of #Resveratrol> activation of SIRT1 > SIRT1 is associated with the induction of angiogenesis, fibroplasia, and collagen organisation. [1.3] [#Metabolic syndrome, #Obesity] - Several genes that encode long noncoding RNAs (lncRNAs). One of these genes, called Snhg9, varied in abundance in animals depending on the presence or absence of gut microbiota mediated by immune effectors. - lncRNA interacted with and bound to cell cycle and apoptosis protein 2, which in turn bound to and inhibited sirtuin, a regulator of lipid metabolism. - High levels of Snhg9 seen in germ-free mice may be the reason that they stay slim, whereas animals with intact microbiota have lower levels of the lncRNA and are fatter. [1.4] [#Diabetes Type 2] - #Vitamin D supplementation may improve DM type 2 by decreasing glycosylated hemoglobin (HbA1c) and increasing sirtuin 1 (SIRT1) and #Irisin in #Vitamin D-deficient patients with DM type 2 [1.5] [#Inflamatory bowel disease] - #Resveratrol displayed autophagy-promoting properties in cultured macrophages through sirtuin modulation, highlighting its potential to counteract the macrophagic autophagy dysfunction underlying IBD.References Notes[ ]
