Guar gum {51111352} Record Keys Definition:Guar gum Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:Diet Host: Human Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Multiple Sclerosis] [#Short Chain Fatty Acid] - Individual dietary fiber sources have distinct impacts on T cell subsets - The dietary fiber guar gum impairs Th1 polarization and alters migratory potential - Guar gum elevates short-chain fatty acids but does not impact regulatory T cells - Guar gum supplementation significantly delays autoimmune neuroinflammation [1.2] - guar gum primarily enriches Actinobacteriota, specifically #Bifidobacterium. [#Antibiotic Therapy] - guar gum containing diet (GuD) increased the susceptibility to colonic inflammation. - Amelioration of #Colitis in GuD-fed group pre-treated with antibiotics suggest a vital role of intestinal microbiota in GuD-mediated exacerbation of intestinal inflammation. - Colonic #IL-18 and tight junction markers were also decreased in the GuD-fed group. - Guar gum > luminal accumulation of intermediary metabolites #Succinate and #Lactate in the GuD-fed mice. [1.3] - soluble fiber #Inulin or guar gum, but not insoluble fiber cellulose, promoted colorectal tumorigenesis in AOM-treated and Apcmin/+ mice. - Soluble fiber induced gut dysbiosis with #Bacteroides uniformis enrichment and #Bifidobacterium pseudolongum depletion, accompanied by increased fecal #Butyrate and serum #Bile Acids and decreased #Inosine.References Notes[ ]
