Proteus ⇒ Proteus mirabilis {10000254} Record Keys Parent:Proteus Definition:Proteus mirabilis Details Initialisation date:2020-09-30 Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] [1.2] [#Atherosclerosis, #CVD] - gut microbiota-dependent metabolism of dietary #Phenylalanine into #Phenylacetic acid (PAA) is critical in #Phenylacetylglutamine (PAGln) production, a metabolite linked to atherosclerotic cardiovascular disease (ASCVD). - PPFOR is the main contributor for PAA production in #Bacteroides thetaiotaomicron. - PPDC plays an important role in PAA generation in Proteus mirabilis. - PPFOR and PPDC contribute to PAA production and PAGln formation in colonized hosts. - Gut microbial ppdc and ppfor homolog abundances are each associated with ASCVD in humans. [1.3] [#Parkinson’s Disease] [#Alpha-synuclein] - oral administration of Proteus mirabilis, increased markedly in PD mouse models, was sufficient to provoke selective death of #Dopamine neurons and motor deficits in mice, accompanied by neuroinflammation and accumulation of aggregates of α-synuclein in both the colon and brainReferences Notes[ ]
