Acetaldehyde {90000581} Record Keys Parent:[ ] Definition:Acetaldehyde Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Oncogenesis Notes: [ ]Shared Reference Notes [1.1] [#Cancer] [#Alcohol Consumption] - Genus #Neisseria had extremely high ADH activity and produced significant amounts of acetaldehyde in vitro. - #Neisseria’s ability to produce acetaldehyde was more than 100-fold higher than that produced by #Streptococcus sp., Stomatococcus sp., or #Moraxella sp. - #Neisseria can be a regional source of carcinogenic acetaldehyde and may thus play an essential role in alcohol-related carcinogenesis in humans [#Streptococcus gordonii, #Streptococcus mitis, #Streptococcus oralis, #Streptococcus salivarius, #Streptococcus sanguinis] [#Alcohol Consumption] - Several oral microbial species such as #Streptococci S. gordonii, S. mitis, S. oralis, S. salivarius, S. sanguinis, and #Candida yeasts possess the enzyme alcohol dehydrogenase (ADH), which metabolizes alcohol to acetaldehyde, which is indisputably carcinogenic. [1.2] [#Indole-3-acetic acid] - #Blastocystis ST4 expresses the gene product of acetaldehyde dehydrogenase - This specific gene product potentially plays a role in the degradation of I3AA to IAA. [1.3] - #Ethanol as the metabolite most affected by loss of cross-feeding in individuals with #Colorectal cancer (CRC). - Moderate to heavy #Alcohol Consumption is associated with a 1.17 – 1.44 higher risk of developing CRC via a process that is at least partially mediated by the microbiome, as gut bacteria metabolise #Ethanol to produce the carcinogenic acetaldehyde [1.4] [#Cancer, #Head & Neck cancer, #Oral cancer] [#Alcohol Consumption] - alcohol dehydrogenase enzyme found in different #Candida species enables them to produce acetaldehyde that is highly toxic, mutagenic, and carcinogenicReferences Notes[ ]
