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Shared Reference Notes
- [1.1] [#Amyotrophic lateral sclerosis]
- Tissue sections from different regions of the CNS of ALS patients contain fungi. - fungal structures such as yeast and hyphae in the motor cortex, the medulla and the spinal cord, in eleven patients with ALS. - Some fungal structures were localized intracellularly and even intranuclearly, indicating that this infection is not the result of post-mortem colonization. - PCR analysis and next generation sequencing of DNA extracted from frozen neural tissue identified a variety of fungal genera including #Candida, #Malassezia, #Fusarium, #Botrytis, Trichoderma and #Cryptococcus.