Fibroblast growth factor 21 {90000598} Record Keys Parent:[ ] Definition:Fibroblast growth factor 21 Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Metabolic associated fatty liver disease] [#Resistant starch] - The serum level of FGF21 was found to be significantly reduced after the 4-month RS intervention. - FGF21 > alleviation of #Dyslipidemia and NAFLD. - circulating FGF21 is paradoxically elevated in individuals with NAFLD > FGF21 resistance in analogy to obesity-associated insulin and leptin resistance. - aberrant FGF21 signaling has been suggested as a key pathological step in the development and progression of NAFLD. [#Metabolic associated fatty liver disease, #Obesity] - both circulating and hepatic levels of FGF21 in obese mice were markedly reduced by #Exercise training, where the FGF21 sensitivity in adipose tissue was enhanced. [#Metabolic associated fatty liver disease] [#Resistant starch] - decreased serum level of FGF21 in participants after RS intervention and in mice receiving feces from RS-fed donors,. - increased expression of its receptor complex and downstream effector in adipose tissue.References Notes[ ]
