Paenibacillaceae ⇒ Paenibacillus {10001171} Record Keys Parent:Paenibacillaceae Definition:Paenibacillus Details Initialisation date:[ ] Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - gut microbe–derived metabolite trimethylamine N-oxide (#TMAO), enhanced antitumor immunity to Pancreatic ductal adenocarcinoma (PDAC) - Delivery of #TMAO intraperitoneally or via a dietary choline supplement to orthotopic PDAC-bearing mice reduced tumor growth, associated with an immunostimulatory tumor-associated macrophage (TAM) phenotype, and activated effector T cell response in the tumor microenvironment. - #TMAO potentiated the type I interferon (IFN) pathway and conferred antitumor effects in a type I IFN–dependent manner. - bacteria producing an enzyme that generates #TMA was associated with positive immunotherapy outcomes in people with #Pancreatic Cancer. - #Bacillus and Paenibacillus species, were present at higher levels in people who survived for a long period of time after #Pancreatic Cancer. [1.2] - Other important #Firmicutes genera are #Listeria, Paenibacillus, #Staphylococcus, #Streptococcus, #Pediococcus, and #Leuconostoc.References Notes[ ]
