IL-18 {90000559}

Record Keys
Parent:[  ]
Definition:
IL-18
Queue:[  ]

Details
Initialisation date:[  ]
Specification:
[  ]
Source:
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Meta Information
Structural Type:[  ]
Functional Type:[  ]
Function:
Pro-inflammatory

Notes:

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Shared Reference Notes

  • [1.1] [#TNF-alfa] 
    - anti-inflammatory cytokines (IL-4 and #IL-10) and proinflammatory cytokines (TNF-a, #IL-1b, #IL-2, #IL-6, #IL-8, #IL-12, #IL-17, and IL-18) are significantly changed by #Lactobacillus rhamnosus GG (LGG)
  • [1.2] [#Short Chain Fatty Acid] 
    - SCFAs trigger the generation of #Prostaglandin E2 and the #IL-10 levels by stimulating GPCRs, and can also activate inflammasomes, promoting the production and secretion of IL-18.
  • [1.3] [#Short Chain Fatty Acid] 
    - short-chain fatty acids (SCFAs) > modulate mucosal immunity in the intestine; by sending a signal through guanine nucleotide-binding proteins (G-protein) coupled receptors, SCFAs stimulate enterocyte production of IL-18 and they act directly on the Treg, regulating its size and role
  • [1.4] [#Guar gum] 
    - Colonic IL-18 and tight junction markers were also decreased in the GuD-fed group.

References Notes

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