IL-18 {90000559} Record Keys Parent:[ ] Definition:IL-18 Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Pro-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#TNF-alfa] - anti-inflammatory cytokines (IL-4 and #IL-10) and proinflammatory cytokines (TNF-a, #IL-1b, #IL-2, #IL-6, #IL-8, #IL-12, #IL-17, and IL-18) are significantly changed by #Lactobacillus rhamnosus GG (LGG) [1.2] [#Short Chain Fatty Acid] - SCFAs trigger the generation of #Prostaglandin E2 and the #IL-10 levels by stimulating GPCRs, and can also activate inflammasomes, promoting the production and secretion of IL-18. [1.3] [#Short Chain Fatty Acid] - short-chain fatty acids (SCFAs) > modulate mucosal immunity in the intestine; by sending a signal through guanine nucleotide-binding proteins (G-protein) coupled receptors, SCFAs stimulate enterocyte production of IL-18 and they act directly on the Treg, regulating its size and role [1.4] [#Guar gum] - Colonic IL-18 and tight junction markers were also decreased in the GuD-fed group.References Notes[ ]
