Citrulline {90000466}

Shared Reference Notes

• [1.1] [#Ceramides] [#Aging] 
  - Among metabolites that were positively associated with age, seven were common in all four groups (aconitic acid, #Choline, citrulline, #Cysteine, cystine, #kynurenine, and symmetric dimethylarginine (SDMA)) and 10 were common in three out of four groups (aspartic acid, asymmetric dimethylarginine (ADMA), butyrylcarnitine, ceramide d18:1/24:1, ceramide d18:1/25:0, ceramide d18:2/24:1, hippuric acid, homocysteine, methionine sulfoxide, and #p-cresol #Sulfate)
• [1.2] 
  - Citrulline (CIT) (commonly found as l–citrulline), a non-essential amino acid with unique metabolic properties, has been implicated in several regulatory roles, including gut modulation, antioxidative and anti-inflammatory effects, protein synthesis, nitrogen homeostasis, blood pressure regulation, renal function, cardiac function, skeletal muscle function, vascular health, lipid and energy metabolism, #Arginine production, and thermoregulation. - citrulline is largely concentrated in watermelon (Citrullus lanatus (Thunb.) Matsum. & Nakai Cucurbitaceae) fruits, but although present in vegetative tissues (such as stems, seedlings, and leaves) and root, citrulline is confirmed to progressively accumulate majorly in the fruit flesh and rind tissues of watermelons. - Within the small intestine, citrulline is synthesized from glutamine by the enterocytes, releasing citrulline into blood circulation for metabolism into #Arginine by the kidneys.

References Notes