Blautia hominis {50002828} Record Keys Parent:[ ] Definition:Blautia hominis Details Initialisation date:[ ] Meta Information Rank:[ ] Domain:[ ] Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Crohn’s disease] [#Clostridioides difficile, #Clostridium paraputrificum] [#Fecal Microbiota Transplantation] - Transferred fecal microbiota from healthy patients and patients with defined Crohn’s ileocolitis (CD_L3) to germ-free mice > a markedly reduced engraftment of CD_L3 microbiome compared to healthy control microbiota. - FMT from CD_L3 patients did not lead to ileitis but resulted in #Colitis with features consistent with CD: a discontinued pattern of #Colitis, more proximal colonic localization, enlarged isolated lymphoid follicles and/or tertiary lymphoid organ neogenesis, and a transcriptomic pattern consistent with epithelial reprograming and promotion of the Paneth cell-like signature in the proximal colon and immune dysregulation characteristic of CD. - The observed inflammatory response associated with persistently increased abundance of #Ruminococcus gnavus, #Erysipelatoclostridium ramosum, #Faecalimonas umbilicate, Blautia hominis, #Clostridium butyricum, and C. paraputrificum and unexpected growth of toxigenic C. difficile.References Notes[ ]
