Vagotomy {51111369} Record Keys Definition:Vagotomy Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:[ ] Host:[ ] Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] - #Alpha-synuclein fibrils injected into gut induce #Alpha-synuclein pathology which spreads from gut to brain, and that vagotomy stops the spread. - persons who had complete truncal vagotomy decades earlier had substantially reduced incidence of PD later in life [1.2] [#Depression] - inoculation of healthy mice with GM from UCMS mice activates the Vagus Nerve and induces early and sustained changes in both #Serotonin and #Dopamine neurotransmission pathways in the brainstem and HPC. - Vagotomy abrogates adult HPC neurogenesis deficits, neuroinflammation and depressive-like behavior, suggesting that vagal afferent pathways are necessary to drive GM-mediated effects on the brain. [1.3] [#Lipopolysaccharide] - Preclinical studies have verified that subdiaphragmatic vagotomy blocked the development of #Depression-like behaviors in rodents after LPS injection or #Fecal Microbiota Transplantation (FMT) from Chrna7 knock-out mice with #Depression-like behaviorsReferences Notes[ ]
