Lantibiotics {90000297} Record Keys Parent:[ ] Definition:Lantibiotics Queue:[ ] Details Initialisation date:2022-06-03 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:Cytokine Function:Anti-bacterial Notes: [ ]Shared Reference Notes [1.1] [#Staphylococcus hominis] - S. hominis is another CoNS that produces lantibiotics, a class of cyclic AMPs containing lanthionine and methyllanthionine [1.2] [#Streptococcus mutans] - oral lantibiotics (it has a considerable antimicrobial effect on intestinal gram-positive bacteria) produced by S. mutans decrease the diversity of intestinal microbes and reduce the abundance of #Firmicutes [1.3] - the lantibitoic #Nisin binds to the lipid II, which is responsible for #Peptidoglycan synthesis, thus interfering with cell wall biosynthesis of target bacteria. In addition, its C-terminal region leads to the formation of pores that result in membrane disruption and efflux of bacterial metabolites necessary for growth. [1.4] - Lantibiotics are ribosomally synthesized and posttranslationally modified peptides (RiPPs) that are produced by bacteria. [1.5] - Othe peptide antimicrobials include the #Colicins of #Escherichia coli, the #Pyocins of #Pseudomonas aeruginosa, the #Halocins of #Halobacteria, #Subtilin of #Bacillus subtilis, the lantibiotics of #Lactic acid bacteria (LAB), and other #Bacteriocins. [1.6] - Epilancins constitute an until now underexplored family of lantibiotics with an unknown ecological role and unresolved mode of action. - an epilancin in the nasal isolate #Staphylococcus epidermidis A37 specifically active against natural corynebacterial competitors. - A37 enters the corynebacterial cytoplasm through a partially transmembrane-potential-driven uptake without impairing the cell membrane function. - A37 induces the formation of intracellular membrane vesicles, which are heavily loaded with the compound and are essential for the antibacterial activity of the epilancin.References Notes[ ]
