Microbiome & Chronic Diseases

Evidence Based Medicine
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Neonate {51111321}

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Shared Reference Notes

  • [1.1
    - Although the microbiota in neonates is established at birth, it will shape throughout the next 3 years of life due to environmental factors such as diet, antibiotics, hygiene, and the built environment
  • [1.2
    - there is a critical neurodevelopmental window shortly after birth, where dysbiosis can have severe long-term consequences to hippocampal function and so learning and memory via altered microbiomes and their metabolites.
  • [1.3] [#Vaginally delivery
    - Infant gut metabolomes were less diverse than maternal but featured hundreds of unique metabolites and microbe-metabolite associations not detected in mothers. - delivery mode, breastfeeding, use and type of infant formula, and prior antibiotics significantly influenced infant microbiomes or metabolomes for at least one sampling time point. - Early infant colonizers #Streptococcus thermophilus and #Lactobacillus acidophilus transiently expanded around the time of delivery, whereas #Anaerotruncus colihominis, a species with potential immunomodulatory properties was fleetingly reduced.

References Notes

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