Neonate {51111321}

Shared Reference Notes

• [1.1] 
  - Although the microbiota in neonates is established at birth, it will shape throughout the next 3 years of life due to environmental factors such as diet, antibiotics, hygiene, and the built environment
• [1.2] 
  - there is a critical neurodevelopmental window shortly after birth, where dysbiosis can have severe long-term consequences to hippocampal function and so learning and memory via altered microbiomes and their metabolites.
• [1.3] [#Vaginally delivery] 
  - Infant gut metabolomes were less diverse than maternal but featured hundreds of unique metabolites and microbe-metabolite associations not detected in mothers. - delivery mode, breastfeeding, use and type of infant formula, and prior antibiotics significantly influenced infant microbiomes or metabolomes for at least one sampling time point. - Early infant colonizers #Streptococcus thermophilus and #Lactobacillus acidophilus transiently expanded around the time of delivery, whereas #Anaerotruncus colihominis, a species with potential immunomodulatory properties was fleetingly reduced.

References Notes