Aggregatibacter ⇒ Aggregatibacter actinomycetemcomitans {10000870} Record Keys Parent:Aggregatibacter Definition:Aggregatibacter actinomycetemcomitans Details Initialisation date:[ ] Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Chronic periodontitis, #Periodontal disease] - Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (#Leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs). [1.2] [#Enterobacteriaceae bacterium] - the oral bacterium in the duodenum may be capable of entering the pancreas. For instance, the periodontal microbes (#Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans) have been proven positively related to #Pancreatic Cancer risk [1.3] - Some oral #Bacteria (e.g., #Porphyromonas gingivalis, #Prevotella intermedia, Aggregatibacter actinomycetemcomitans, and #Fusobacterium nucleatum) produce volatile #Sulfur compounds (VSCs), such as #Hydrogen sulfide (H2S), methyl mercaptan (CH3SH), dimethyl #Sulfide ((CH3)2S), and dimethyl disulfide (CH3SSCH3). [#Pancreatic Cancer] - In pancreatic cancers, in addition to #Fusobacterium nucleatum and #Porphyromonas gingivalis, strains of Aggregatibacter actinomycetemcomitans, #Neisseria elongata, and #Streptococcus mitis have been described. [1.4] [#Parkinson’s Disease, #Periodontal disease] - decrease in A. actinomycetemcomitans levels in the PA+PD group [1.5] [#Lipopolysaccharide] - The main pathogenic factors attributed to A. actinomycetemcomitans include #Leukotoxin, LPS, surface-associated materials, and various enzymes [#Alzheimer’s disease] [#Amyloid-beta, #Lipopolysaccharide] - LPS from serotype B of A. actinomycetemcomitans, > trigger high levels of proinflammatory cytokine production in microglia and an increase the secretion of the Aβ1-42 peptide > ADReferences Notes[ ]
