IL-17A {60000086}

Notes:

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[1.1]
- IL-17A is expressed in mucosal cells and contributes to intestinal homeostasis but might promote inflammation in excess. - IL-17A is mainly produced by Th17 cells. It can also be produced by γδ T cells, natural killer (NK) T cells, macrophages, neutrophils, and eosinophils, but their regulation of IL-17A expression is different. - IL-17 molecules from the gut can influence autoimmune diseases in the central nervous system by regulating the gut microbiota rather than directly triggering brain inflammation
[1.2] [#Parkinson’s Disease]
- #Collinsella was associated with a higher level of pro-inflammatory IL-17A, > exacerbate neuroinflammation especially microglial activation in PD rodent model
[1.3]
- The peptide “YLYDGRIFI” similar to human Sm antigen epitope from #Odoribacter splanchnicus increased secretion of IFN-γ and IL-17A.
[1.4] [#Chronic fatigue syndrome]
- Fluctuations in IL-17 have been associated with #Fatigue and #Fatigue severity in ME/CFS patients
- IL-17A has been found to be associated with neurological sequelae and pulmonary #Fibrosis in post-#Covid-19 patients
[1.5] [#Multiple Sclerosis]
- MS > bacterial species more abundant in clinically active treatment-naïve cases were positively associated with circulating levels of pro-inflammatory cytokines #IL-22, IL-17A, IFN-β, IL-33, and TNF-α.

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