Sulforaphane {90000231} Record Keys Parent:[ ] Definition:Sulforaphane Queue:[ ] Details Initialisation date:2022-01-09 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Sulforaphane can normalize the intestinal flora imbalance of #Bladder cancer mice with a significant increase in #Bacteroides fragilis and #Clostridium cluster I [1.2] - Sulforaphane is a naturally occurring, potent antioxidant, found in Brassicaceae plants such as #Broccoli, and is being considered for use in the treatment of #Fibrosis, #Cancer and preeclampsia - Under anaerobic conditions, the enteropathogenic #Escherichia coli strain EPEC E2348/69 showed the most significant increases in growth in the presence of sulforaphane. - In aerobic conditions, sulforaphane was shown to have an antimicrobial effect on EPEC E. coli ECE2348/69 - decrease in oxygen concentration, sulforaphane may not provide antioxidant functions [1.3] [#Cruciferous vegetables] - Cruciferous diet can supply GSLs such as glucoraphanin (GLR), sinigrin, and glucoerucin, which are metabolized by plant-sourced myrosinase and gut microbiota-sourced enzymes into isothiocyanates (ITCs), such as sulforaphane (SFN) and erucinReferences Notes[ ]
