L-Dopa {60000080}
| Parent: | [ ] |
|---|---|
| Definition: | L-Dopa |
| Queue: | [ ] |
| Initialisation date: | 2020-09-29 |
|---|---|
| Specification: | |
| [ ] | |
| Source: | |
| [ ] | |
| Structural Type: | [ ] |
|---|---|
| Functional Type: | Neurotransmitter |
| Function: | [ ] |
Notes:
[ ]
Shared Reference Notes
- [1.1] [#Parkinson’s Disease]
- [1.2] [#Parkinson’s Disease]
- Tyrosine decarboxylase (TyrDC), present in gut microbes, converts L-dopa into #Dopamine, which does not cross the blood-brain barrier and accumulates in the gut, causing many side effects such as cardiac arrhythmias and nausea. - levodopa can be metabolized by Clostridium sporogenes to 3-(3,4-dihydroxyphenyl) propionic acid (#DHPPA), a metabolite that inhibits muscle contraction in the ileum, reduces intestinal movement, and impairs absorption in the small intestine. - [1.3] [#Parkinson’s Disease] [#Dopamine]
- [1.4] [#Parkinson’s Disease] [#Prevotella copri]
- patients with early stage PD, who did not receive anti-Parkinson treatment, levodopa (L-DOPA), maintained a significantly lower relative abundance of P. copri
References Notes
[ ]