L-Dopa {60000080} Record Keys Parent:[ ] Definition:L-Dopa Queue:[ ] Details Initialisation date:2020-09-29 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:Neurotransmitter Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] [1.2] [#Parkinson’s Disease] - Tyrosine decarboxylase (TyrDC), present in gut microbes, converts L-dopa into #Dopamine, which does not cross the blood-brain barrier and accumulates in the gut, causing many side effects such as cardiac arrhythmias and nausea. - levodopa can be metabolized by Clostridium sporogenes to 3-(3,4-dihydroxyphenyl) propionic acid (#DHPPA), a metabolite that inhibits muscle contraction in the ileum, reduces intestinal movement, and impairs absorption in the small intestine. [1.3] [#Parkinson’s Disease] [#Dopamine] [1.4] [#Parkinson’s Disease] [#Prevotella copri] - patients with early stage PD, who did not receive anti-Parkinson treatment, levodopa (L-DOPA), maintained a significantly lower relative abundance of P. copriReferences Notes[ ]
