DHPPA {90000302}

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3-(3,4-dihydroxyphenyl) propionic acid

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Shared Reference Notes

  • [1.1] [#Parkinson’s Disease
    - Tyrosine decarboxylase (TyrDC), present in gut microbes, converts #L-Dopa into #Dopamine, which does not cross the blood-brain barrier and accumulates in the gut, causing many side effects such as cardiac arrhythmias and nausea. - levodopa can be metabolized by Clostridium sporogenes to 3-(3,4-dihydroxyphenyl) propionic acid (DHPPA), a metabolite that inhibits muscle contraction in the ileum, reduces intestinal movement, and impairs absorption in the small intestine.

References Notes

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Common References

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