Disease ⇒ Gallbladder cancer {40000614}

Shared Reference Notes

• [1.1] 
  - #Salmonella enterica activates the MAPK-AKT pathway in mouse and cell-line models of gallbladder cancer
• [1.2] [#Salmonella typhimurium] 
  - increased abundance of #Salmonella in the gut microbiome of patients with Gallbladder cancer (GBC) and culturable #Salmonella Typhimurium from their GBC tissue. - Comparative genomics of S. Typhimurium isolated from GBC tissue showed a high invasive index. S. Typhimurium isolates harbored horizontally acquired potential virulence functions in their accessory genome. - Chronic S. Typhimurium infection displayed inflammation, pre-neoplastic changes and tumor promoting mechanisms in a mouse model with gallbladder stones, including activation of the epigenetic modulator Kdm6b. Inhibition of Kdm6B reduced tumor size in NOZ cells engrafted in SCID-mice.
• [1.3] [#Biliary tract cancer, #Colorectal cancer, #Esophageal cancer, #Pancreatic Cancer] 
• [1.4] 
  - #Primary sclerosing cholangitis (PSC), an immune-associated cholangitis, is linked to a heightened risk of cholangiocarcinoma and gallbladder cancer
• - The dominant species identified in the bile of gallbladder cancer patients included #Fusobacterium nucleatum, #Escherichia coli, and #Enterobacter sp., while the bile from cholelithiasis patients primarily contained #Escherichia coli, #Salmonella sp., and #Enterococcus gallinarum
• - #Peptostreptococcus stomatis and #Enterococcus faecium were identified as potential contributors to the progression of gallbladder cancer
• - the ability of #Salmonella enterica to facilitate the transformation of genetically predisposed cells, ultimately acting as a causative agent of gallbladder cancer. - This bacterium induces malignant transformation in susceptible mice, murine gallbladder organoids, and fibroblasts by triggering TP53 mutations and c-MYC amplification
• - The chronic presence of #Salmonella typhi in gallbladder disease may contribute to the onset of gallbladder cancer

References Notes