Citrobacter ⇒ Citrobacter rodentium {10000222}

Shared Reference Notes

• [1.1] 
  - Switching mice from a standard grain-based rodent chow to a high-fat, low-fiber #Western-style diet resulted in a rapid reduction in the number of gut bacteria. - Mice fed the #Western-style diet were frequently unable to clear the pathogen Citrobacter rodentium from the colon. They were also prone to developing chronic infection when re-challenged by this pathogen.
• [1.2] [#Pectin] 
  - Pectins > anti-inflammatory properties on intestinal immunity > direct interactions on Toll-like receptors (TLRs) in the small intestine or via stimulating microbiota-dependent effects in the large intestine. - Pectins> prevent C. rodentium induced colonic inflammation > lowering the C. rodentium load in the caecum independently of the DB.
• [1.3] [#Vitamin A] 
  - Commensal segmented filamentous bacteria protect against C. rodentium infection - Commensal bacteria express enzymes that generate #Retinoic acid in the intestine - Commensal bacterial-derived #Retinoic acid promotes epithelial defense in the host

References Notes