Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Tauro-cholic acid {90000459}

Record Keys

Parent:[  ]
Tauro-cholic acid
Queue:[  ]


Initialisation date:[  ]
[  ]
[  ]

Meta Information

Structural Type:[  ]
Functional Type:[  ]
Function:[  ]


[  ]

Shared Reference Notes

  • [1.1] [#Clostridium difficile associated disease] [#Primary bile acids
    - #Bile Salt hydrolases (BSHs) comprise a diverse family of microbial enzymes that catalyse critical BA transformation. - Primary conjugated BAs synthesized in the liver, such as the tauro- and glycoconjugates of #Cholic acid (TCA, GCA), are deconjugated by BSHs to generate #Cholic acid (CA)
  • [#Clostridium difficile associated disease] [#Clostridioides difficile] - TCA acts as a germinant for C. difficile spores, whereas #Chenodeoxycholic acid (CDCA) can inhibit germination and growth
  • [1.2] [#Candida albicans
    - C. Albicans infection could be promoted by intestinal taurocholic acid (TCA) that weakens mucosal innate and adaptive immune responses
  • [1.3
    - high #Sugar conditions directly limit murine and human colonoid development, which is associated with a reduction in the expression of proliferative genes, ATP levels and the accumulation of #Pyruvate. - Treatment of colonoids to force #Pyruvate into the Tauro-cholic acid cycle, restored their growth. - high #Sugar diet led to massive irreparable damage that was independent of the colonic microbiota and its metabolites. Analyses on crypt cells.

References Notes

[  ]

Common References