3,3′-Diindolylmethane {90000610} Record Keys Parent:[ ] Definition:3,3′-Diindolylmethane Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - 3,3′-Diindolylmethane (DIM), in mitigating the pathogenicity of the oral biofilm inhabiting bacterium #Streptococcus mutans, a bacterium that is considered to be a principal etiological agent in dental #Caries. - DIM was able to attenuate S. mutans biofilm formation by 92%. - treatment with DIM lowered extracellular polymeric substance (EPS) production and decreased its durability significantly under acidic conditions. [1.2] [#Constitutive androstane receptor , #Diabetes Type 2, #Metabolic associated fatty liver disease] - CAR plays a critical role in regulating the breakdown, uptake and removal of foreign substances in the liver, including drugs. - CAR plays a role in diabetes, fatty liver disease and small intestine #Ulcerative Colitis - The diindoles, diindolylmethane (DIM) and #Diindolylethane (DIE) selectively up-regulate bona fide CAR target genes in primary human hepatocytes and mouse liver without causing significant side effects. References Notes[ ]
