E-cadherin {90000578} Record Keys Parent:[ ] Definition:E-cadherin Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Cancer] [#IL-1b] - IL-1β was linked to lower expression of E-cadherin, which promotes cell migration - Low E-cadherin expression is correlated with disorders of cellular functions, growth inhibition, apoptosis, cell cycle arrest, and differentiation. It leads to aggressive carcinoma, higher invasiveness, and low patient survival [#Fusobacteria] - fusobacterial adhesin/invasin FadA, which binds to E-cadherin on carcinoma cells and activates β-catenin signaling. This pathway results in enhanced transcriptional activity of Wnt, activation of pro-inflammatory cytokines, oncogenes, and stimulation of #Cancer cells proliferation [1.2] - Enterotoxigenic #Bacteroides fragilis (ETBF) produces toxins that target the tight junctions of intestinal epithelial cells, cleaving E-cadherin and promoting inflammation and destruction of the intestinal mucosal barrier. [1.3] [#Colorectal cancer] [#Fusobacterium nucleatum] - F. nucleatum is suggested to enhance CRC progression through its FadA adhesin, which attaches to epithelial cadherin (E-cadherin) and may activate the Wnt/β-catenin signaling pathway86 leading to enhanced proliferation [1.4] [#Bacteroides fragilis] [#Bacteroides fragilis toxin] - Specific strains of B. fragilis excrete a toxin known as B. fragilis toxin (BFT), which is a metalloprotease capable of cleaving E-cadherins > increases gut permeability and may lead to leaky gut. [1.5] [#Oral squamous cell carcinoma] - oral cavity squamous cell carcinoma (OSCC) > #Fusobacterium nucleatum might contribute to cellular invasion via crosstalk with E-cadherin/β-catenin signaling, TNFα/NF-κB pathway and extracellular matrix remodeling by up-regulating SNAI2 gene, a key transcription factor of epithelial-mesenchymal transition (EMT). [1.6] [#Akkermansia muciniphila] - Akkermanicia mucinophilia produce > #Amuc_1409 promotes the proliferation and regeneration of intestinal stem cells (ISCs). - It turns out this protein interacts directly with E-cadherin on the surface of ISCs > triggers a cascade of events that leads to the activation of the Wnt/β-catenin signaling pathway, a key regulator of ISC function. - More ISCs, faster regeneration of the gut lining, and improved overall gut healthReferences Notes[ ]
