Indole-3-carbinole {90000491} Record Keys Parent:[ ] Definition:Indole-3-carbinole Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Indole-3-acetic acid, #Pyruvic acids] - #AHR, especially in barrier tissues of the respiratory and gastrointestinal, can also be activated by dietary and microbial indole-derived metabolites such as pyruvic acid (IPyA), indole acetic acid (IAA), #Indoxyl-3-sulfate, indole-3-carbinole (I3C), and 3,3′-di-indolylmethane (DIM). [1.2] - I3C is converted in the stomach by acid-mediated condensation into various byproducts, including high affinity #AHR ligands DIM and #Indole[3,2-b] carbazole (ICZ) - The main class of dietary #AHR ligands is indoles, including #Indole-3-acetonitrile, #Indole-3-carbinole (I3C), 3,3’-diindolylmethane (DIM) and Indolo(3,4)bicarbazole, which are found mainly in cruciferous vegetables like #Broccoli or Brussel sproutsReferences Notes[ ]
