Nisin {90000304}

Shared Reference Notes

• [1.1] [#Chronic periodontitis] [#Lactobacillus lactis] [#Nisin probiotic] 
  - Nisin and a nisin-producing Lactococcus lactis probiotic significantly decreased the levels of several periodontal pathogens, alveolar bone loss, and the oral and systemic inflammatory host response. - Surprisingly, nisin and/or the nisin-producing L. lactis probiotic enhanced the population of fibroblasts and osteoblasts despite the polymicrobial infection.
• [1.2] [#Lantibiotics] 
  - the lantibitoic nisin binds to the lipid II, which is responsible for #Peptidoglycan synthesis, thus interfering with cell wall biosynthesis of target bacteria. In addition, its C-terminal region leads to the formation of pores that result in membrane disruption and efflux of bacterial metabolites necessary for growth.
• [1.3] 
• [1.4] [#Lactococcus lactis] 
  - oral administration of L. lactis strain NZ3900 pre-stimulated with nisin significantly limited the formation of a fatty liver phenotype and the progression of early #Atherosclerosis in a rabbit model fed a high #Cholesterol diet.
• [#Fusobacterium nucleatum, #Porphyromonas gingivalis, #Treponema denticola] - nisin has concentration-dependent antimicrobial activity against Gram-negative periodontopathic bacteria such as P.gingivalis, T.denticola, and F.nucleatum
• - genes involved in #Iron binding and #Iron-#Sulfur cluster binding were increased in the livers of infected mice, but suppressed by nisin treatment
• - at the species level, the abundance of #Lactobacillus gasseri in the gut and liver microbiomes was increased in the nisin and the infection+nisin groups
• [#Metabolic associated fatty liver disease] [#Lactococcus lactis] - oral administration of nisin, a bacteriocin produced primarily by L. lactis, shifted the oral, gut, and liver microbiome toward a new state commensurate with health > prevented periodontal disease and enteritis, and subsequently reduced the bacterial exposure in the liver > marked protective effect against vacuolar degeneration and fat deposition in the liver
• - treatment with nisin alone significantly reduced the microbiome diversity in the small intestine
• - nisin treatment of polymicrobial-infected mice significantly suppressed the expression of oxidative phosphorylation-related genes in mitochondria and peroxisomes, including cytochrome P450
• - gene expression of molecules involved in lipid metabolism, PPARα and CYP2E1, was also increased in infected mice, but significantly reduced by nisin treatment.
• - nisin attenuates #Periodontal disease-induced hepatic lipidation and lipid peroxidation.

References Notes