Leukotoxin A [LtxA] {60000113}
Parent: | [ ] |
---|---|
Definition: | Leukotoxin A |
Queue: | LtxA |
Initialisation date: | 2020-10-23 |
---|---|
Specification: | |
[ ] | |
Source: | |
[ ] |
Structural Type: | [ ] |
---|---|
Functional Type: | [ ] |
Function: | [ ] |
Notes:
[ ]
Shared Reference Notes
- [1.1] [#Chronic periodontitis, #Periodontal disease]
- #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).
References Notes
[ ]