Leukotoxin A [LtxA] {60000113}
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| Definition: | Leukotoxin A |
| Queue: | LtxA |
| Initialisation date: | 2020-10-23 |
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Shared Reference Notes
- [1.1] [#Periodontal disease, #Chronic periodontitis]
- #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).
References Notes
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