Leukotoxin A [LtxA] {60000113}
| Parent: | [ ] |
|---|---|
| Definition: | Leukotoxin A |
| Queue: | LtxA |
| Initialisation date: | 2020-10-23 |
|---|---|
| Specification: | |
| [ ] | |
| Source: | |
| [ ] | |
| Structural Type: | [ ] |
|---|---|
| Functional Type: | [ ] |
| Function: | [ ] |
Notes:
[ ]
Shared Reference Notes
- [1.1] [#Chronic periodontitis, #Periodontal disease]
- #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).
References Notes
[ ]