Sign ⇒ Seizure {40000592} Record Keys Type:Disease, Sign Parent:[ ] Definition:Seizure Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - excessive neuronal activity accelerates glycolysis to generate #Lactate, which translocates to the extracellular space to slow neuronal firing and inhibit excitatory transmission via HCA1R. These studies may identify novel anticonvulsant target and seizure termination mechanisms. [1.2] [#Drug-resistant Epilepsy] [#Keto diet] - #Reactive Oxygen Species is elevated during seizure activity due to #Oxidative stress-associated neuronal death, which can further contribute to epileptogenesis. - The KD reportedly reduces #Oxidative stress by promoting antioxidant enzymatic activity. [#Branched-chain amino acids] - BCAA derivatives are reported to promote G-protein phosphorylation, and abnormalities in GPCR-mediated neuronal signaling can contribute to seizure susceptibility.References Notes[ ]
