Ornithine {90000398} Record Keys Parent:[ ] Definition:Ornithine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Chronic fatigue syndrome] - #Glutamine and ornithine serum levels in ME/CFS were lower, and correlated with metabolites linked to the urea cycle. [1.2] [#Chronic fatigue syndrome] - #Covid-19 > The increased ornithine/#Citrulline ratio level in class B patients reflects abnormal metabolic activity in the urea cycle. - a similarly increased ornithine/#Citrulline ratio in CFS patients [1.3] - #Arginine metabolism mainly produces urea and ornithine via the arginase pathway and #Nitric Oxide (NO) and #Citrulline via the #Nitric Oxide synthase (NOS) pathway [1.4] - #Neisseria meningitidis, the bacteria responsible for #Meningococcal disease, produces N-3-hydroxypalmitoyl-ornithine which serves selectively as an agonist for sphingosine-1-phosphate receptor 4 (S1PR4), a GPCR that has a role in human inflammatory responsesReferences Notes[ ]
