Primary bile acids ⇒ Chenodeoxycholic acid {90000427} Record Keys Parent:Primary bile acids Definition:Chenodeoxycholic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - The primary bile acid profile in #Infants predominantly consists of #Cholic acid (CA) and chenodeoxycholic acid (CDCA), with a greater proportion of CA and its conjugates than CDCA and its conjugates [1.2] [#Clostridium difficile associated disease] [#Clostridioides difficile] [#Tauro-cholic acid] - TCA acts as a germinant for C. difficile spores, whereas chenodeoxycholic acid (CDCA) can inhibit germination and growth [1.3] [#Polycystic ovary syndrome] - PCOS > reduction of bile acid (#Glycodeoxycholic acid and #Tauroursodeoxycholic acid) and #IL-22 secretion - administration of chenodeoxycholic acid could improve PCOS phenotypes in mice experiments. [1.4] [#Metabolic associated fatty liver disease] [#Bile Acids] - Patients with MAFLD show elevated levels of total fecal BAs, including #Cholic acid and chenodeoxycholic acid, along with an altered balance of primary and secondary BAs. [#Metabolic associated fatty liver disease] - in mafld > lean patients exhibited lower levels of #Deoxycholate, #Glycochenodeoxycholic acid, and chenodeoxycholic acid but higher levels of #Glycocholic acid compared to nonlean patients.References Notes[ ]
