Oral administration of Blautia wexlerae {51111347} Record Keys Definition:Oral administration of Blautia wexlerae Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:Probiotic Host: Mouse Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Diabetes Type 2] [#Blautia wexlerae] - Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with #Obesity and type 2 diabetes mellitus. - Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet–induced #Obesity and diabetes. - The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and L-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. - S-adenosylmethionine, acetylcholine, and L-ornithine have anti-inflammatory properties and modify aspects of host metabolism, such as lipid metabolism, indicating that these compounds are potential effector metabolites for controlling #Obesity and diabetes.References Notes[ ]
