IL-23 {90000577} Record Keys Parent:[ ] Definition:IL-23 Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#IL-1b, #TNF-alfa] - Periodontal pathogens affect growth of local concentrations of various cytokines including interleukin-1β (IL-1β), #IL-6, #IL-17, IL-23, tumor necrosis factor-α (TNF-α), and matrix metalloproteinases MMP-8 and MMP-9 [1.2] [#Reactive arthritis] - #Indole induces pathogenic antibody formation through class switching to IgG2b as well as decreased antibody sialyation that enhances complement fixation, and that these changes may occur through the IL-23/Th17 axis. [1.3] - Intestinal nematode infections trigger the activation of the host immune system, including the #IL-17 and IL-23 pathways. - #IL-17 may promote inflammatory responses leading to tissue damage, but may also play a role in parasite clearance.References Notes[ ]
