OmpC {90000535} Record Keys Parent:[ ] Definition:OmpC Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Crohn’s disease, #Inflamatory bowel disease, #Ulcerative Colitis] [#Escherichia coli] - Most UC, and to a lesser extent CD patients develop peri-nuclear anti-neutrophil cytoplasmic antibodies (pANCA). - These antibodies cross-react with the E. coli membrane porin C (OmpC) protein, suggesting a possible role for B cell autoreactivity and gut microbial antigenic cross-reactivity in the pathogenesis of IBD [#Crohn’s disease] [#Escherichia coli, #Saccharomyces cerevisiae] - CD patients have increased serum titers of antibodies against the E. coli membrane porin C (OmpC), yeast S. cerevisiae #Mannose epitopes (ASCA) and bacterial flagellins (CBir) and both the presence and titers of these antibodies are associated with disease severity.References Notes[ ]
