Skatole {90000235} Record Keys Parent:[ ] Definition:Skatole Queue:[ ] Details Initialisation date:2022-01-09 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Indole-3-acetic acid, #Indole-3-propionic acid, #Tryptophan] - TRP > utilized by the intestinal flora in the intestinal tract and metabolized into ligand molecules indole, indole propionic acid, indole acetic acid, skatole, and #Tryptamine > action on of aryl hydrocarbon receptor (AHR). [1.2] [#Indole-3-acetamide (IAM), #Indole-3-acetic acid, #Indole-3-aldehyde, #Indole-3-lactic acid, #Indole-3-propionic acid, #Indole-3-pyruvic acid (IPyA), #Indoleacrylic acid (IA)] - For AhR, the most effective Trp metabolites are #Indole, skatole, IA, #Tryptamine, IPyA and #Indole-3-acetamide (IAM), whereas IAA, IAID, IPA and ILA are the least active [1.3] [#Autism] [#Butanoic acid, #Propanoic acid] - GM core volatilome for all ASD patients was characterized by over-production of 1-pentanol, 1-butanol, phenyl ethyl alcohol; benzeneacetaldehyde, octadecanal, tetradecanal; #Methyl isobutyl ketone, 2-hexanone, acetone; acetic, propanoic, 3-methyl-butanoic and 2-methyl-propanoic acids; #Indole and skatole; and o-cymene. [#Autism] - #Indole and skatole concentrations were increased in children with ASD. - #Indole was more represented in ASD subgroups characterized by low severity symptoms and without GI symptoms [#Autism] - #Tryptophan derivatives such as #Indole and skatole were significantly increased (p ≤ 0.05) in #Children with ASD, particularly skatole, and thus were also identified as biomarkers by the ML predictive model.References Notes[ ]
