Glycans ⇒ Sialic acid {90000249} Record Keys Parent:Glycans Definition:Sialic acid Queue:[ ] Details Initialisation date:2022-01-17 Specification: [ ]Source: [ ] Meta Information Structural Type:Carbohydrate Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Glycans] [1.2] [#Alzheimer’s disease] - #Neisseria gonorrhoeae and Group B Streptococcus selectively bind huCD33 as part of immune evasive molecular mimicry of host SAMPs. - Human cells synthesize two forms of CD33: a full-length version and a mutated, inactive form that lacks the sugar-binding site. Those with a particular point mutation—different by a single changed nucleotide—produce a higher proportion of the mutant CD33, reducing the immune system’s ability to recognize sialic acids. [1.3] [#Citrobacter rodentium] - C. rodentium was able to catabolize sialic acid, a monosaccharide derived from mucins, and utilize it as its sole carbon source for growth. - C. rodentium also sensed and displayed chemotactic activity toward sialic acid. These activities were abolished when the nanT gene, encoding a sialic acid transporter, was deleted (ΔnanT). - the ΔnanT C. rodentium strain was significantly impaired in its ability to colonize the murine intestine. Intriguingly, sialic acid was also found to induce the secretion of two autotransporter proteins, Pic and EspC, which possess mucinolytic and host-adherent properties. - sialic acid enhanced the ability of C. rodentium to degrade intestinal mucus (through Pic), as well as to adhere to intestinal epithelial cells (through EspC).References Notes[ ]
