Syndrome ⇒ antiphospholipid syndrome {40000629} Record Keys Type:Syndrome Parent:[ ] Definition:antiphospholipid syndrome Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Anti-β2-glycoprotein I/HLA-DR (anti-β2GPI/HLA-DR) antibody has been reported to be associated with antiphospholipid syndrome and recurrent pregnancy loss (RPL). [1.2] [#Systemic lupus erythematosus] - In mice, intake of a #Ginger extract (either by oral gavage or mixed with chow) reduced NETosis in models of APS and lupus. - This was accompanied by a decrease in disease-relevant phenotypes, including thrombosis in the setting of APS and autoantibody formation in the setting of lupus [#Systemic lupus erythematosus] [#Antimicrobial peptides, #Gingerols] - 6-gingerol, the most abundant bioactive phytochemical in #Ginger root, inhibited neutrophil phosphodiesterase (PDE) activity, boosting intracellular cyclic AMP (cAMP) levels and thereby counteracting neutrophil hyperactivity in mouse models of APS and lupus [1.3] [#Sjögren syndrome ] - preceding sinusitis was associated with increased risk of several rheumatic diseases, including antiphospholipid syndrome , Sjögren’s disease , #Vasculitis and #Polymyalgia rheumatica. - Acute sinusitis was also associated with increased risk of seronegative #Rheumatoid Arthritis. - Sinusitis was most associated with any rheumatic disease in the 5-10 years before disease onsetReferences Notes[ ]
