Homocysteine {90000520} Record Keys Parent:[ ] Definition:Homocysteine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Alzheimer’s disease] - #Constipation significantly correlated with a steeper decline in cognitive function and greater increase in DWML volume in patients with AD and aMCI. - higher level of serum homocysteine was observed in those with #Constipation. - patients with #Constipation experienced cognitive decline at a rate over twice that experienced by patients without #Constipation. - #Oxygen radicals might be produced through the cascade of homocysteine metabolism causing endothelial cell damage, and homocysteine could activate matrix metaroproteinase-9, a membrane disrupting agent, leading to a direct influence on the cell membrane. - about 25% of systemic circulating homocysteine is produced by intestinal mucosal cells [#Parkinson’s Disease] - altered gut microbiome, which was observed in PD patients, was reported to contribute to the increase in homocysteine level. - Serum homocysteine level was significantly high in PD patients, and that level was correlated with brain atrophy. - Cognitive decline in PD patients was reported to show higher homocysteine level, lower folate and vitamin B12 levels, although it is unveiled the role of homocysteine in the cognitive decline. [1.2] - High levels of homocysteine enhanced the #Dementia risk attributed to #Air Pollution, while high #Methionine concentrations reduced this risk.References Notes[ ]
