Secondary bile acids ⇒ 3-succinylated cholic acid {90000731} Record Keys Parent:Secondary bile acids Definition:3-succinylated cholic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Akkermansia muciniphila] - 3-sucCA at physiological concentrations can directly promote the growth of A. muciniphila - an inhibitory effect of 3-sucCA on #Clostridium sporogenes and #Enterococcus hirae - #Bacteroides uniformis strains as effective producers of 3-sucCA both in vitro and in vivo. By activity-based protein purification and identification, we identified an enzyme annotated as β-lactamase in B. uniformis responsible for 3-sucCA biosynthesis. [#Metabolic associated fatty liver disease] - 3-succinylated cholic acid (3-sucCA), which is negatively correlated with liver damage in patients with liver-tissue-biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD). [#Metabolic associated fatty liver disease] [#Akkermansia muciniphila] - the beneficial effect of 3-sucCA on MAFLD was reversed by A. muciniphila depletion.References Notes[ ]
