Equol {60000110} Record Keys Parent:[ ] Definition:Equol Queue:[ ] Details Initialisation date:2020-10-23 Specification: - soy ISF metabolite - anti‐oxidant and anti‐amyloidogenicSource: Soy Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Multiple Sclerosis] [#Isoflavone diet] [1.2] [#Phytoestrogen] - gut bacteria can metabolize isoflavones into equol, which has a higher affinity for endogenous estrogen receptors compared to dietary isoflavones. - #Isoflavone-rich diet can protect from neuroinflammatory diseases, and that protection was dependent on the ability of gut bacteria to metabolize isoflavones into equol. - mice on a diet with isoflavones showed an anti-inflammatory response compared to the mice on a diet lacking isoflavones. [1.3] [#Alzheimer’s disease] [#Enterobacteriaceae bacterium] - AD elders were also depleted in #Adlercreutzia equolifaciens, an equol-producing bacterium, which has beneficial effects in reducing experimental cutaneous inflammation in mice and the loss of which has been associated with the neurodegenerative disorder #Multiple Sclerosis. [1.4] - Humans do not have the capacity to metabolize #Phytoestrogen, but certain gut bacteria can metabolize them to produce metabolites such as S-equol (equol) from isoflavones, which shows significantly higher estrogenic activity than the original isoflavones [1.5] - #Eggerthella in humans has been shown to produce equol, a #Phytoestrogen, with estrogenic properties and binding affinity to #Estrogen receptors [1.6] [#Adlercreutzia equolifaciens] [#Soybean] - A. equolofaciens produces the nonsteroidal #Estrogen equol from isoflaven found in soybeans [1.7] [#Autism] - Several known equol producers were consistently higher in controls, including #Slackia and #Adlercreutzia equolifaciens. #Coriobacteriaceae, a family involved in lipid metabolism85 and equol production, was also depleted in #Infants with future NDs. - significant decrease in a potential equol signal in future ASD cases. [#Estrogen] - Equol has been studied for anti-inflammatory effects and estrogenic activity. - equol exhibits blood-brain barrier permeability capability, anti-neuroinflammatory properties, and neuroprotective effects, protecting microglia against #Lipopolysaccharide (LPS)-induced inflammation and neurotoxins.References Notes[ ]
